SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG ZALTOPROFEN BY MIXING SOLVENCY TECHNIQUE

In present work mixed solvency concept was used for solubility enhancement of poorly water soluble drug. Aqueous blends of hydrotropes, cosolvents and water soluble solids were used as solvent for poorly water soluble model drug zaltoprofen. In mixing solvency above additives are mixed in different ratio and their aqueous solution served as solvent for water insoluble drug. These solvent systems have extreme potential of increasing solubility of poorly water soluble drugs. In this research work standard curve of drug in different individual aqueous solution of above mentioned type of substances as well as in their blend were plotted and from the curve, solubility of drug in that solvent system is estimated using excess solute addition method. The results obtained shows that solubility of drug in mixed blend is more as compared to their individual solvent systems.

SOURCE: PHARMATUTOR

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