FORMULATION AND DEVELOPMENT OF VENLAFAXINE HYDROCHLORIDE EXTENDED RELEASE TABLET USING COMPRESSION COATING TECHNIQUE

Venlafaxine HCl is an anti depressent drug which is used in depreesion. It is available both as immediate release tablet as well as modified release product. The innovator modified release product available in international market is Effexor ER tablets. Effexor ER is based on erosion matrix system. The core tablet is coated with Ethyl Cellulose using PVP as a core former. This coating is solvent based coating. The aim of  present investigation was to prepare a ER tablet of Venlafaxine HCl  with similar dissolution profile matching to  Effexor ER  using  swelling  matrix system. The platform developed for this product was compression coating.  An immediate release  core tablet of 100mg  was prepared and it was compression coated using HPMC  matrix system. HPMC of three viscosity grades was selected and the concentration and the   viscosity grade were optimised. Similarity factor ( F2 values) with innovator product were calculated for in vitro dissolution profile.  The  rank order correlation for similarity factor was as under HPMC K15M 15% > HPMC K100M 15% > HPMC k15M 35% > HPMC k100M 35% > HPMCK 4M 15% > HPMC k45 45%. In this review, current and recent developments of venlafaxine hydrochloride extended release products are discussed....

SOURCE: PHARMATUTOR

READ MORE: http://www.pharmatutor.org/articles/formulation-development-venlafaxine-hydrochloride-extended-release-tablet-using-compression-coating-technique