A simple, sensitive, rapid, accurate, precise and economical Fouriertransform infrared (FTIR) spectrophotometric method has been developed for the determination of Azelastine Hydrochloride (AZH) in nasal spray preparations. The IR spectrophotometric method
was based on the determination of AZH by the measurement of the area of
the infrared band corresponding to the carbonyl group centred at the
band1636 cm-1. It was present in the AZH but not in Acetonitrile used as solvent and highest intensity was at the area 1701.08-1584.21 cm-1.
The linearity of AZH was obtained in the concentration range of 5-100
μg/ml. The mean % recovery was 99.67 ± 0.57 %. The recovery studies
confirmed accuracy of proposed method and low values of standard
deviation confirmed precision of method.
SOURCE: PHARMATUTOR.ORG
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