PharmaTutor

Tuesday, November 5, 2013

Jobs for B.Pharm, M.Pharm, D.Pharm, Pharm.D, B.Sc, M.Sc in Nov 2013

JOBS-
Requires a proactive approach and excellent written/oral communication and interpersonal skills. Strong interpersonal skills required to interact with clients, management, and peers effectively.
Partner with global customers and AMRI teams to ensure a coordinated approach from project initiation through to successful close out.
Performs site selection, initiation, monitoring and close out visits in accordance with contracted scope of work and good clinical practices.
IPQA of Dispensing, Manufacturing, Packaging and Dispatch activities.. Review of SOP’s, Protocols, B.P.R’s & other quality and production related

BA/BS in the life sciences, nursing degree, or equivalent combination of education and experience.  Moderate clinical research experience in a contract research organization (CRO), pharmaceutical, or biotechnology company.
IPQA of Dispensing, Manufacturing, Packaging and Dispatch activities; Verification of production related documents.
The person needs to have extensive tissue culture, molecular biology and cell biology expertise to carry out scientific investigations in-depth in the relevant areas of skin health
Degree in Life Science, Business Management or related field and a minimum experience in Contracts, Finance, Proposals, industry specific operations experience
timely requistion of drugs, safe storage of drugs,to assist in ABC & FSN classification, periodical stock checking of concern pharmacy items for quality, short expiry and non moving items.
Degree/Diploma in Pharmacy with minimum 1 year experience in managing a drug store in a reputed hospital/health centre
CSIR scheme entitled "Diversity unexplored analysisa nd documentation of diazotrophic cyanobacteria of chhattisgarh" along with detailed academic biodata
Masters & Doctorate; Knowledge and experience in pharmaceutical drug development. The qualifications and experience prescribed are the minimum and mere possession
Assume the ability to meet the requirements of a CDA I with a high degree of proficiency and autonomy. Take responsibility for specific tasks on projects, or acts as the main CDA contact on individual projects
project on, Biophysical and Structural Aspects of Oncogenic G-Quartets bound to Drugs: Screening, High Resolution NMR and Low Resolution Spectroscopy
West Bengal State Electricity Distribution Company Limited (WBSEDCL), a wholly-owned profit-making and professionally managed Government of West Bengal Enterprise
Prepare, maintain and ensure the execution of Data Entry guidelines, Discrepancy/Edit Check documents, Quality Control Plans
The contractual employment will be for a period of one year subject to review of their conduct and performance during the employment.
Science Graduate With the Knowledge of Computer Applications; IDPL will be conducting interview to fill up the post of Marketing Executive (North Zone)
Ph.D. in Inorganic/Organic/ Analytical Chemistry with research experience in the relevant field. Candidates with experience of research in the area of the project or related field will be preferred.
Maintenance of laboratory as per the research specific regulatory requirements and if needed to meet cGMP/cGLP requirements.  Training and mentoring of team members.
Educational Qualifications, Pay Scales and Service Conditions will be  as per the existing rules of  apex body and Government of Maharashtra.
Candidates should have good knowledge of basic pharmaceutics. He/She should be well versed with concepts of Novel Drug Delivery Systems.
Knowledge of NMR theory and work experience on NMR Spectrometer; Andhra University was constituted in the year 1926 by the Madras Act of 1926...
Bioprocess development of recombinant therapeutics in Pichia pastoris: Human Interleukin-3 (hIL-3) as a model system
Maintain copies of all approved Study Plans and Standard Operating Procedures in use in the test facility
Applicants who have completed their Post Graduate degree in Bioinformatics or any other branch of Life Sciences with knowledge in Bioinformatics. M. Pharm/ B.Tech. in Bioinformatics graduates
Preference shall be given for Experience of working in Pharma manufacturing set up and computer knowledge.
Arranging appointments with doctors, pharmacists and hospital medical teams, which may include pre-arranged appointment or regular cold calling
Develop business in the growing dietary supplement and OTC pharma market especially for Probiotics, Polyols and other pharma ingredients and excipients
Preparation and Execution of Drug Master files of API in CTD and ECTD format, independently in coordination with plant people.
The post carry Pay and Allowances, such as HRA and Traveling allowance etc. at Central Government rates as applicable to the employees of Council
Largest producer of Ayurveda medicines in public sector in India, One among the few Public Sector companies, consistently making profit
PhD in Synthetic Organic Chemistry/Medicinal Chemistry with research publications in high quality international journals
Medical Transcription is the conversion of audio files dictated by the US doctors into text format which contains the detailed patient information.

Ph.D (Algal Biotechnology/ Chemical Engineering/ Biochemical Engineering/ Environmental Biotechnology/ Basic or Applied Microbiology) with some relevant research experience. 

Find detailed info on: http://jobs.pharmatutor.org

ARTICLES -

Tuesday, October 29, 2013

Central Drug Research Institute invite M.Pharm/M.Sc/Ph.D for various vacant positions | 17 posts

Candidates fulfill the eligibility criteria and possess the required qualification as mentioned above, should turn up for walk-in

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Job Opportunity for Pharmacists (82 Posts) in Health Department, National Rural Health Mission | Walk in

D.Pharm, pharmacist act 1948 notification from recognized institution by government. Valid Registration with the pharmacy council of haryana.

READ MORE: 
http://www.pharmatutor.org/pharma-jobs/vacancies/oct13/job-opportunity-pharmacist-in-health-department-national-rural-health-mission-nrhm-haryana-walk-in


SOURCE: PHARMATUTOR.ORG

Career Opportunity for M.Pharm/M.Sc as Junior Research Fellow and Project Assistant Position in RCB-UNESCO


M.Sc./MPharm in Natural (Chemical or Biological) Sciences with/without NET qualified. Experience in synthetic organic chemistry, and analytical techniques like HPLC, NMR, and mass spectrometry

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Vacancies for M.Pharm/Pharm.D as Medical writers @ Medeka Health

Job involves writing scientific articles for Journals - review articles, conference news, case studies, medical news, updates on disease management, controversies in disease management, practice issues

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Work as Assistant Professor as Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical chemistry in Brahmanand College of Pharmacy | 9 Posts

Brahmanand College of Pharmacy (BGI was established by Brahmanand Education & Charitable Trust, Bulandshahr,UP in 2009 at BSR- Khurja G.T. Road, Bulandshahr

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GOODPASTURE SYNDROME

Patients with Goodpasture’s syndrome presenting with dialysis-dependent end-stage renal failure at diagnosis almost never regain independent renal function. We report a patient with a 100% crescentic lesion in whom reversal of dialysis dependence was achieved by immunoadsorption together with immunosuppression. In a second patient, early initiation of...

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A REVIEW ON DETERMINATION OF PRESERVATIVES IN FOOD STUFFS BY DIFFERENT ANALYTICAL METHODS

Majority of instances of food spoilage can be attributed to the attack by pathogens (disease-causing microorganisms ) such as bacteria and molds,  Different methods that had been devised for preserving foods are all designed to reduce or eliminate to the causative agents.  The food preservation refers to techniques

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http://www.pharmatutor.org/articles/review-on-determination-preservatives-food-stuffs-different-analytical-methods



SOURCE: PHARMATUTOR.ORG

SUBJECT RECRUITMENT AND RETENTION AT THE TRIAL SITE

Achieving clinical trial research participant recruitment and retention is essential for conducting a successful trial. Adequate enrollment provides a base for projected participant retention, resulting in evaluative patient data. Obtaining final evaluative data is dependent on successful patient and principal investigator retention. Patients cannot be retained without an initial pool of enrolled volunteers.

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A REVIEW : CHEMICAL PENETRATION ENHENCERS FOR TRANSDERMAL DRUG DELIVERY SYSTEMS

Delivery of the drug via skin would provide a useful alternative to oral route and important site of drug application for local and systemic effects with minimum undesirable side effects. Skin penetration techniques have been developed to improve bioavailability and enhance the range of drugs for which transdermal delivery is a viable option. The permeation of drug through skin can be enhanced by chemical penetration enhancers. The present review article includes the classification of permeation enhancers and their mechanism of action; thus it will help in the selection of suitable penetration enhancer for improving the permeation of poorly absorbed drugs via transdermal route.


TRANSDERMAL A NOVEL DRUG DELIVERY SYSTEM

Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety...

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ESTIMATION OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN TYPE II DIABETIC PATIENTS

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and abnormalities in carbohydrate, fat and protein metabolism. It results from defects in insulin secretion, insulin sensitivity or both. Oxidative stress may play an important role in the itiology of diabetes and Diabetic complications. So, during Diabetes hyperglycemia causes increased production of free radical especially reactive oxygen species(ROS) for all tissues from glucose auto-oxidation and protein glycosylation.

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FIBRODYSPLASIA OSSIFICANS PROGRESSIVA

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of the connective tissue characterized by progressive disability as a result of extensive extra skeletal enchondral bone formation and malformed big toes which are often monophalangic. Occasional features include short thumbs, fifth finger clinodactyly, malformed cervical vertebrae and mild mental retardation. Beginning during childhood, FOP progressively immobilizes all the joints through adult life, rendering movement impossible. Currently, there is no effective prevention or cure for this debilitating disease.

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EVIDENCE-BASED MEDICINE TO PERSONALIZED MEDICINE – A PROSPECTIVE

Evidence-based medicine (EBM) is the process of systematically reviewing, appraising and using clinical research findings to aid the delivery of optimum clinical care to patients. It is a method of healthcare decision-making that intends to combine the most reliable scientific information with individual expertise and patient preferences in order to offer the optimal diagnostic and therapeutic option for the patient. On the other hand, pharmacogenomics is a whole genome application that examines the single gene interactions with drugs. In recent years, the term personalized medicine has been introduced to represent an approach considering differences among individual patients. In modern medicine, the most important sources of evidence are clinical trials using epidemiological methods, and molecular biological and genetic methods characterizing individual patients.

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LIPOSOMES AN OVERVIEW– A NOVEL TREND IN THE DRUG DELIVERY

Liposomes are result of self assembly of phospholipid in an aqueous media resulting in closed bilayered structures. Liposomes are one of unique drug delivery system which can be use in controlling and targeting drug delivery system. Liposomes are generally classified based upon structure, method of preparation, composition and application, conventional liposome, and specialty liposome. Liposomes are formulated and processed to differ in size, composition, charge and lamellarity, depending upon method of preparation either active loading technique or passive loading technique. The prepared liposomes are characterized for visual appearance, liposomal size distribution, lamillarity, liposome stability, entrapped volume and surface charges. Different marketed formulations are available in market for liposomes. The liposomes have many applications which increase its importance over other formulations.

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A REVIEW ON IMPLANTABLE DRUG DELIVERY SYSTEM

There was a need for delivery systems that could maintain a steady release of drug to the specific site of action. Therefore, drug delivery systems were developed to optimize the  therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug...

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http://www.pharmatutor.org/articles/review-implantable-drug-delivery-system



SOURCE: PHARMATUTOR.ORG

Wednesday, October 23, 2013

Pharmacy Job alerts

​​JOBS-
Indian Drugs & Pharmaceuticals Ltd. (IDPL) is a Govt. of India Undertaking Public Sector unit wholly owned by the Govt. of India engaged in manufacture of pharmaceuticals.
M.Sc. in Organic Chemistry/M. Pharma with FIRST division or equivalent grade. project on, The Total Synthesis of the Antimalarial Natural Products, Flinderoles
Good academic record with a doctoral degree in Science (Physics/ Chemistry/ Life Science/Biotechnology/Pharmaceutical Sciences)
Three years (as per the duration of the project) with an initial appointment for one year, and subsequently renewable for two more years after performance evaluation.
Experience in the field of genetics, molecular biology, high altitude research. Research experience in molecular biology, protein expression and protein purification
Diploma in Pharmacy course, passed from any of 3 Govt. Medical Colleges of the State or from any AICTE approved/Pharmacy Council of India
Meeting with Stockiest make the products availability. Chemist survey for better marketing. Managing the sales & marketing operations.
Requires a proactive approach and excellent written/oral communication and interpersonal skills. Strong interpersonal skills required to interact with clients, management, and peers effectively.
Candidates widtrolevant research experience in Computer Assisted Drug Designing. In silico designing of multi targeted agents for the treatment of diabetic complications
A Master’s degree in Chemistry/Pharmaceutics/Pharmacy or related scientific field and including significant experience leading activites in a GMP environment.
PhD in Molecular Biology/ Biotechnology/ Biological sciences. Experience in NGS technology. Knowledge on SOliD / IonTorrent/ Competitor platforms will be desired.
B.Pharm. Degree with 1st class and MBA in Markeing (2 years' full time course) with 1st class from a reputed Institute / University.
The Department of Bioinformatics Karunya University, Coimbatore, Tamil Nadu, cordially invites you to participate in the National Conference on "Biological Compelxity.

FInd more jobs at: http://jobs.pharmatutor.org

ARTICLES -

Monday, October 14, 2013

PharmaTutor Job Alerts

JOBS-
M.Sc. in Organic/Pharmaceutical Chemistry/ M.Pharma; M.Sc. in Biotechnology/ Microbiology/ Pharmacology with 55% marks.
Graduate in any discipline with Post-graduate Diploma/ Degree in Marketing from a reputed University/ Institute preferably MBA
Educational Qualifications, Pay Scales and Service Conditions will be as per the existing rules of apex body and Government of Maharashtra.
Diploma in Pharmacy and 3 months training in Pharmacy. Registration with Central / State Pharmacy Council with duly allotted Registration Number is essential.
The period of engagement should be initially for a period of 11 months and renewed based on the performance as decided by the concerned RKS.
Educational Qualifications,  Pay Scales and Service Conditions will be as per the existing rules of apex body and Government of Maharashtra.
D. Pharma with PGDCA/DCA with adequate knowledge of computer particularly in MS-Office. (applicant having higher qualification can also apply but no additional advantage will be given)
Masters in Organic Chemistry/ Pharmaceutical Chemistry; Emoluments are as per DST Norms and salary would be in the range of 14000-16000
Responsible for execution of the assigned laboratory experiments; project for Process R&D and large scale up.
Find more jobs at: http://jobs.pharmatutor.org
ARTICLES- 

Friday, October 11, 2013

IMPROVEMENT OF SOLUBILITY OF LOW SOLUBLE (BCS CLASS 2) DRUGS BY NOVEL DRUG SOLUTION DROPPED TECHNIQUE

The dissolution rate of drug from tablet is affected by its active ingredient’s surface area and consequently, affects in oral bioavailability of the product. The development of formulations containing poorly-water-soluble drugs for oral delivery can be achieved by improving their dissolution. It has been found that increasing the available surface area by reducing the particle size can often markedly improve dissolution rates and lead to...

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BUCCAL MUCOSA AS NOVEL DRUG DELIVERY PLATFORM

Buccal drug delivery had lately become an important route of drug administration. The rich in vascularization of oral mucosa and its permeability too many drugs make this route an attractive alternative to the oral and parenteral routes for systemic drug delivery. Drug delivery via the oral mucous membrane was considered to be a promising alternative to the oral route. Sublingual route was a useful when rapid onset of action was desired with better patient compliance than orally ingested tablets. 

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HERBAL PLANTS A RELIABLE SOURCE FOR DRUG DISCOVERY AND DEVELOPMENT

Though remarkable success have been achieved in the discovery and development of various drugs for the treatment and management of several ailments, there is still need for more discoveries. This is due to the reason that some of the drugs currently in use posseses one or more of the following drawbacks (i) high toxicity level (ii) increase lose of effectiveness or low efficacy (iii) costly or (iv) inaccessable. Herbs have now become the main stream for drug discovery and development. Conservative estimate have revealed that there are over 250,000 higher plant species, and only a minute proportion have been screened exhaustively for their possible therapeutic properties. Atleast, over 120 unique pharmacological substances derived from plants are currently being used as drugs in various countries in the world. Apart from the direct use of plant derivatives as therapeutic agents, they can also serve as models for the design, synthesis or semisynthesis of other therpeutic agents. In conclusion, herbs are a reliable source for more discovery and development of new drugs. The scientific community should therefore harness this resource by improving research on it.

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BE AWARE OF ROHYPNOL: A SHORT COMMUNICATION

Scientific research on drug abuse indicates this as being a rising trend among the youth around the globe. An investigation into the experimentation with drugs among the youth showed a rate of increase of 8%. The study also revealed an 85.9% increase in alcohol use and 35.2% increase in tobacco use.  Furthermore, the study also suggests an increase in the rate of ecstasy and alcohol usage coupled with drugs and opiates such as heroin.  This article will thus endeavour to form a network of Civil Society Organisations (CSOs) whose purpose will be the development and implementation of a joint action plan to prevent substance abuse in around the world, in order to promote active engagement of civil society in this field.


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A REVIEW ARTICLE ON TRANSDERMAL DRUG DELIVERY SYSTEM

Transdermal drug delivery system (TDDS) is topically administered dosage form in the form of patches which deliver drugs for systemic effects at a predetermined and controlled rate. This review focuses towards the basic facts about the transdermal drug delivery system including the methods of their preparation and some of the recent advancements that have in achieved in this field.


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FORMULATION AND CHARACTERIZATION OF RALOXIFENE BETA-CYCLODEXTRINE INCLUSION COMPLEX FOR SOLUBILITY ENHANCEMENT

Raloxifene is a second genaration selective estrogen receptor modulator used to prevent osteoporosis in postmenopausal women. which is insoluble in water and half life is 27.7 hr. it has estrogen effect on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue. raloxifene needs enhancement of solubility and dissolution rate to improve its oral bipavailability and therapeutic efficasy. among  the various approaches to enhance solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrine is an effective and indutrially accepted technique. In the present  investigation complexation of raloxifene with β-CD was carried out by using various technique like physical blending method, kneading method, solvent evaporation method and co-precipitation method. From the various characterization studies like solubility determination, drug content determination, production yield & in vitro dissolution study, it was observed that there was a significant rise in the aqueous solubility and dissolution rate of the raloxifene from the β-cd incusion complex. from the result of statistical analysis, batch RLX-6 by kneading method was found to be optimised batch, because of the maximum enhancement in solubility and rate of dissolution.  Optimised batch was also studied for compatibility by FTIR studies, and also it was found to be stable for the period of 90 days as per the ICH guidelines.



Friday, October 4, 2013

DEVELOPMENT AND VALIDATION OF IR SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF AZELASTINE HYDROCHLORIDE IN NASAL SPRAY PREPARATIONS

A simple, sensitive, rapid, accurate, precise and economical Fouriertransform infrared (FTIR) spectrophotometric method has been developed for the determination of Azelastine Hydrochloride (AZH)   in nasal spray preparations. The IR spectrophotometric method was based on the determination of AZH by the measurement of the area of the infrared band corresponding to the carbonyl group centred at the band1636 cm-1. It was present in the AZH but not in Acetonitrile used as solvent and highest intensity was at the area 1701.08-1584.21 cm-1. The linearity of AZH was obtained in the concentration range of 5-100 μg/ml. The mean % recovery was 99.67 ± 0.57 %. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method.



A VISIT ON PHARMACEUTICAL INDUSTRIAL ORIENTATION

A pharmaceutical formulation and its research invasis play important role in the young generation of the pharmacy students because without seeing the process we don’t know about the formulation and development of any medicine because of that a industrial visit should be compulsory to the pharmacy students. Pharmaceutical industry is a most diverse, R&D oriented, hypercompetitive and knowledge sensitive industry. Competitive intelligence (CI) is a process of ethically and systemic data gathering from operating system to draw important business conclusions. Use of CI for drawing important conclusions regarding present scenario and future forecasting is very important and growth determining practice of pharmaceutical industries. Intellectual property rights (IPR) is an integral part of the industry and IPR related information is freely available in public patent databases. By analyzing patents company can derive important conclusion regarding competitor’s R&D activities, quality of research, collaboration and alliance and can convert this information to knowledge which can play important role in taking future decisions. Present review is fully focused on advent of IPR in getting very good information regarding competitor’s strategies and tactics.


Thursday, October 3, 2013

Walk in interview for the post of Junior Research Fellow in Periyar University

M.Sc. Biotechnology/ Molecular Biology/ Microbiology/ Botany/ Zoology/ Life Science or Equivalent degree with first class.

READ MORE: http://www.pharmatutor.org/pharma-jobs/vacancies/oct13/walk-in-interview-post-junior-research-fellow-in-periyar-university

SOURCE: PHARMATUTOR.ORG

Job as Pharmacist in Zilla Parishad Yavatmal - 3 posts

Applicants are required to have qualification in Diploma in pharmacy from any recognized university. And registered as pharmacist through 1948 act.

READ MORE: http://www.pharmatutor.org/pharma-jobs/vacancies/oct13/invites-pharmacist-in-zilla-parishad-yavatmal

SOURCE: PHARMATUTOR.ORG

Job for Ayurvedic Pharmacist in GSFDSL

Bachelor in Pharmacy/Bachelor in Ayurvedic, Preferences will be given to masters in  Chemistry, Bhaijaya kalpana, Dravya gun specialization from Recognized ayurvedic universities

READ MORE: http://www.pharmatutor.org/pharma-jobs/vacancies/oct13/job-ayurvedic-pharmacist-in-gujarat-state-forest-development-corporation-limited

SOURCE: PHARMATUTOR.ORG

Opening for Patent Coordinator in Novo Nordisk

A bachelor’s degree in any discipline with an excellent academic record is required. About one year of relevant job experience handling patent administrative tasks is essential.



Walk in for Research Associate in National Centre for Cell Science

Ph.D. in any branch of life science or Equivalent Degree or 3 years of research experience after M.Tech / MVSc / M.Pharm as demonstrated by Peer - Reviewed Publications.

READ MORE: http://www.pharmatutor.org/pharma-jobs/vacancies/oct13/walk-in-research-associate-in-national-centre-cell-science

SOURCE: PHARMATUTOR.ORG

Application are invited for post of Pharmacist in LGBRIMH

Bachelor’s Degree in B. Pharm from a recognized University/Institution. Registration under Pharmacy Council.


Walk in interview for the post of Pharmacist in Central Railway

Two years Diploma in Pharmacy and registration with Pharmacy Council of India.Central Railway covers a large part of the state of Maharashtra and parts of North-Eastern Karnataka and Southern Madhya Pradesh.


A NOVEL RP- HPLC METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN AND FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

The present investigation describes about a simple, economic, selective, accurate, precise reverse phase high performance liquid chromatographic method for the simultaneous estimation of Atorvastatin and Fenofibrate in pure and pharmaceutical dosage forms. Atorvastatin and Fenofibrate were well separated using a Thermohypersil BDS C18column of dimension 100 × 4.6, 5µm and Mobile phase consisting of  Methanol: Water (Adjusted with orthophosphoric acid to pH-2) in the ratio of 40:60v/v at the flow rate 1 ml/min and the detection was carried out at 274nm with PDA detector. The Retention time for Atorvastatin and Fenofibrate were found to be 1.438, 2.949 respectively. The developed method was validated for recovery, specificity, precision, accuracy, linearity according to ICH guidelines. The method was successfully applied to Atorvastatin and Fenofibrate combination pharmaceutical dosage form..


A SHORT REVIEW ON- COMMON PLANTS WITH THEIR EXTRAORDINARY BENEFICIAL EFFECT ON THE TREATMENT OF DIABETES MELLITUS

Herbal medicines derived from medicinal plants are used by about 60% of the world’s population. This review focuses on some medicinally rich plants used in the treatment of diabetes worldwide. Diabetes is an important metabolic disorder and at present, approximately 18-20 million people are diabetic in India. Diabetic complications  like nephropathy, retinopathy, coronary artery disease, stroke, Peripheral vascular disease etc are affected more rapidly not in mega-city but also urban area in India. Cost of the treatment of these complications are also hiked day by day. Insulin and Oral hypoglycemic agents which are marketed for diabetes are costly than herbal medicine and it is very difficult to bear for urban people. In this paper medicinal plants with proven antidiabetic and related beneficial effects used in treatment of diabetes are discussed. These Plants are Emblica officinalis ,Azadirachta indica, Allium sativum, Annona squamosa, Aegle marmelos, Elephantopus scaber, Musa Paradisiaca, Andrographis Paniculata, Mangifera indica.


NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN POTASSIUM AND AMLODIPINE DRUGS IN PURE AND PHARMACEUTICAL DOSAGE FORMS

A fast, robust and accurate RP-HPLC method was developed and validated for simultaneous determination of Losartan potassium and Amlodipine in tablets. The mobile phase was mixture of aqueous Tri ethyl amine with pH 2.0 and Acetonitrile(70:30), effluent flow rate monitored at 1.0 ml/min. the stationary phase was C18 column, 3µm(4.6×250mm). The solutions of standard and the sample were prepared in methanol. The retention times was found to be 2.916min and 5.214min for Losartan potassium and Amlodipine respectively at 246nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of 50-150µg/ml. The percentage assay for Losartan potassium and Amlodipine were found to be 101% and 100%respectively. The method was validated and it was found to be accurate, precise, linear and reproducible as per ICH guidelines.


FILM COATING TECHNOLOGY: AN OVER VIEW

Film coating technology is now a days very important in the field of pharmacy particularly in formulation development. In the last 25 years tablet coating has undergone several fundamental changes. Many modifications were advocated to improve the basic process and film coating chosen in place of sugar coating. Film coating is the process whereby a tablet, capsule, or pellet is surrounded by a thin layer of polymeric material. Tablet film coating is performed by two types, one is aqueous film coating (generally water is used as a solvent) and non aqueous film coating (generally organic solvent are used). Film coating formulations usually contain Polymer, Plasticizer, Colourants / Opacifiers, Solvent / Vehicle. Many film coating materials have functional properties which enable the creation of sustained or delayed (enteric) release dosage forms. Coating solution composition may affect the quality of final coated tablets. Optimization of composition of film coating solution is also required. This article discusses tablet coating process, film coating, process parameters, film coating advantages and applications, components of film coating, evaluation of film coated tablets, film defects etc.