Venlafaxine HCl is an anti depressent drug which is used in depreesion. It is available both as immediate release tablet as well as modified release product. The innovator modified release product available in international market is Effexor ER tablets. Effexor ER is based on erosion matrix system. The core tablet is coated with Ethyl Cellulose using PVP as a core former. This coating is solvent based coating. The aim of present investigation was to prepare a ER tablet of Venlafaxine HCl with similar dissolution profile matching to Effexor ER using swelling matrix system. The platform developed for this product was compression coating. An immediate release core tablet of 100mg was prepared and it was compression coated using HPMC matrix system. HPMC of three viscosity grades was selected and the concentration and the viscosity grade were optimised. Similarity factor ( F2 values) with innovator product were calculated for in vitro dissolution profile. The rank order correlation for similarity factor was as under HPMC K15M 15% > HPMC K100M 15% > HPMC k15M 35% > HPMC k100M 35% > HPMCK 4M 15% > HPMC k45 45%. In this review, current and recent developments of venlafaxine hydrochloride extended release products are discussed....
SOURCE: PHARMATUTOR
READ MORE: http://www.pharmatutor.org/articles/formulation-development-venlafaxine-hydrochloride-extended-release-tablet-using-compression-coating-technique
Lyme disease (Lyme borreliosis) is an infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu strictois the main cause of Lyme disease in North America, whereas Borrelia afzelii and Borrelia garinii cause most European cases. The disease is named after the towns of Lyme and Old Lyme, Connecticut, US, where a number of cases were identified in 1975. Although it was known that Lyme disease was a tick-borne disease as far back as 1978, the cause of the disease remained a mystery until 1981, when B. burgdorferi was identified by Willy Burgdorfer....
SOURCE: PHARMATUTOR
READ MORE: http://www.pharmatutor.org/articles/overview-lyme-disease
In
present work mixed solvency concept was used for solubility enhancement
of poorly water soluble drug. Aqueous blends of hydrotropes, cosolvents
and water soluble solids were used as solvent
for poorly water soluble model drug zaltoprofen. In mixing solvency
above additives are mixed in different ratio and their aqueous solution
served as solvent for water insoluble drug. These solvent systems have extreme potential of increasing solubility of
poorly water soluble drugs. In this research work standard curve of
drug in different individual aqueous solution of above mentioned type of
substances as well as in their blend were plotted and from the curve, solubility of drug in that solvent system is estimated using excess solute addition method. The results obtained shows that solubility of drug in mixed blend is more as compared to their individual solvent systems.
SOURCE: PHARMATUTOR
READ MORE: http://www.pharmatutor.org/articles/solubility-enhancement-poorly-water-soluble-drug-zaltoprofen-mixing-solvency-technique
Major depression is a mood disorder
characterized by a sense of inadequacy, despondency, decreased
activity, pessimism and sadness where these symptoms severely disrupt
and adversely affect the person’s life, sometimes to such an extent that
suicide is attempted or results. Various Strategies are used for the treatment of depression by giving drug by various routes. Nasal drug delivery is the best route for treatment of CNS disorder as it is the direct route for the delivery of drug.
SOURCE: PHARMATUTOR
READ MORE: http://www.pharmatutor.org/articles/brain-drug-delivery-nanoparticles-nasal-route-treatment-depression
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