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Thursday, October 3, 2013

Walk in for Research Associate in National Centre for Cell Science

Ph.D. in any branch of life science or Equivalent Degree or 3 years of research experience after M.Tech / MVSc / M.Pharm as demonstrated by Peer - Reviewed Publications.

 READ MORE: http://www.pharmatutor.org/pharma-jobs/vacancies/oct13/walk-in-research-associate-in-national-centre-cell-science

 SOURCE: PHARMATUTOR.ORG
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Application are invited for post of Pharmacist in LGBRIMH

Bachelor’s Degree in B. Pharm from a recognized University/Institution. Registration under Pharmacy Council.

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Walk in interview for the post of Pharmacist in Central Railway

Two years Diploma in Pharmacy and registration with Pharmacy Council of India.Central Railway covers a large part of the state of Maharashtra and parts of North-Eastern Karnataka and Southern Madhya Pradesh.
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A NOVEL RP- HPLC METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN AND FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

The present investigation describes about a simple, economic, selective, accurate, precise reverse phase high performance liquid chromatographic method for the simultaneous estimation of Atorvastatin and Fenofibrate in pure and pharmaceutical dosage forms. Atorvastatin and Fenofibrate were well separated using a Thermohypersil BDS C18column of dimension 100 × 4.6, 5µm and Mobile phase consisting of  Methanol: Water (Adjusted with orthophosphoric acid to pH-2) in the ratio of 40:60v/v at the flow rate 1 ml/min and the detection was carried out at 274nm with PDA detector. The Retention time for Atorvastatin and Fenofibrate were found to be 1.438, 2.949 respectively. The developed method was validated for recovery, specificity, precision, accuracy, linearity according to ICH guidelines. The method was successfully applied to Atorvastatin and Fenofibrate combination pharmaceutical dosage form..


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A SHORT REVIEW ON- COMMON PLANTS WITH THEIR EXTRAORDINARY BENEFICIAL EFFECT ON THE TREATMENT OF DIABETES MELLITUS

Herbal medicines derived from medicinal plants are used by about 60% of the world’s population. This review focuses on some medicinally rich plants used in the treatment of diabetes worldwide. Diabetes is an important metabolic disorder and at present, approximately 18-20 million people are diabetic in India. Diabetic complications  like nephropathy, retinopathy, coronary artery disease, stroke, Peripheral vascular disease etc are affected more rapidly not in mega-city but also urban area in India. Cost of the treatment of these complications are also hiked day by day. Insulin and Oral hypoglycemic agents which are marketed for diabetes are costly than herbal medicine and it is very difficult to bear for urban people. In this paper medicinal plants with proven antidiabetic and related beneficial effects used in treatment of diabetes are discussed. These Plants are Emblica officinalis ,Azadirachta indica, Allium sativum, Annona squamosa, Aegle marmelos, Elephantopus scaber, Musa Paradisiaca, Andrographis Paniculata, Mangifera indica.


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NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN POTASSIUM AND AMLODIPINE DRUGS IN PURE AND PHARMACEUTICAL DOSAGE FORMS

A fast, robust and accurate RP-HPLC method was developed and validated for simultaneous determination of Losartan potassium and Amlodipine in tablets. The mobile phase was mixture of aqueous Tri ethyl amine with pH 2.0 and Acetonitrile(70:30), effluent flow rate monitored at 1.0 ml/min. the stationary phase was C18 column, 3µm(4.6×250mm). The solutions of standard and the sample were prepared in methanol. The retention times was found to be 2.916min and 5.214min for Losartan potassium and Amlodipine respectively at 246nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of 50-150µg/ml. The percentage assay for Losartan potassium and Amlodipine were found to be 101% and 100%respectively. The method was validated and it was found to be accurate, precise, linear and reproducible as per ICH guidelines.


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FILM COATING TECHNOLOGY: AN OVER VIEW

Film coating technology is now a days very important in the field of pharmacy particularly in formulation development. In the last 25 years tablet coating has undergone several fundamental changes. Many modifications were advocated to improve the basic process and film coating chosen in place of sugar coating. Film coating is the process whereby a tablet, capsule, or pellet is surrounded by a thin layer of polymeric material. Tablet film coating is performed by two types, one is aqueous film coating (generally water is used as a solvent) and non aqueous film coating (generally organic solvent are used). Film coating formulations usually contain Polymer, Plasticizer, Colourants / Opacifiers, Solvent / Vehicle. Many film coating materials have functional properties which enable the creation of sustained or delayed (enteric) release dosage forms. Coating solution composition may affect the quality of final coated tablets. Optimization of composition of film coating solution is also required. This article discusses tablet coating process, film coating, process parameters, film coating advantages and applications, components of film coating, evaluation of film coated tablets, film defects etc.


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